沈晶  (SHEN, Jing)

博士，研究员，硕士研究生导师。

邮箱：crystal_stray@126.com

办公室地址：四川省泸州市龙马潭区商贸城17区B座3层5街川南医学转化研究院

      个人简介

2013年于香港中文大学获得博士学位，完成3年博士后研究工作。2018年迄今为西南医科大学教授，硕士研究生及博士后导师。擅长非编码RNA及表观遗传调控在肿瘤中的作用及机制研究。目前是国家自然科学基金，四川省科技厅项目评审专家，Current Pharmaceutical Design杂志客座编辑； Immunity & Ageing, Biomedicine & Pharmacotherapy,    Bioengineered等二十余个杂志的特邀审稿人。曾主持科研项目6项，其中国家级课题2项，省部级1项，总经费200余万元；近年来先后在Acta Pharmaceutica Sinica B、Autophagy、Theranostics等国际重要期刊发表SCI论文70余篇，申请发明专利1项，出版学术专著1部。2022年被评为四川省学术技术带头人后备人选，四川省泸州市龙马潭区优秀无党派人士，西南医科大学优秀硕士生导师，四川省最美家庭。

 代表性论文

1. Xiao M, Pang C, Xiang S, Zhao Y, Wu X, Li M, Du F, Chen Y, Wang F, Wen Q, Xiao Z, Yang Z, Shen J*. Comprehensive characterization of B7 family members in NSCLC and identification of its regulatory network. Sci Rep. 2023 Mar 15;13(1):4311.

2. Yang L, Zou T, Chen Y, Zhao Y, Wu X, Li M, Du F, Chen Y, Xiao Z, Shen J. Hepatitis B virus X protein mediated epigenetic alterations in the pathogenesis of hepatocellular carcinoma. Hepatol Int. 2022 Aug;16(4):741-754.

3. Chen Y, Zheng A, Zhang Y, Xiao M, Zhao Y, Wu X, Li M, Du F, Chen Y, Chen M, Li W, Li X, Sun Y, Gu L, Xiao Z, Shen J*. Dysregulation of B7 family and its association with tumor microenvironment in uveal melanoma. Front Immunol. 2022 Oct 14;13:1026076.

4. Dai Y, Yang L, Sakandar A, Zhang D, Du F, Zhang X, Zou L, Zhao Y, Wang J, Zhang Z, Wu X, Li M, Ling X, Yu L, Dong L, Shen J, Xiao Z, Wen Q. Vemurafenib inhibits immune escape biomarker BCL2A1 by targeting PI3K/AKT signaling pathway to suppress breast cancer. Front Oncol. 2022 Nov 29;12:906197.

5. Luo S, Jiang Y, Anfu Zheng, Zhao Y, Wu X, Li M, Du F, Chen Y, Deng S, Chen M, Li W, Li X, Gu L, Sun Y, Xiao Z, Shen J*. Targeting hypoxia-inducible factors for breast cancer therapy: A narrative review. Front Pharmacol. 2022 Dec 1;13:1064661.

6. Zhao Q, Zhao Y, Hu W, Zhang Y, Wu X, Lu J, Li M, Li W, Wu W, Wang J, Du F, Ji H, Yang X, Xu Z, Wan L, Wen Q, Li X, Cho CH, Zou C, Shen J, Xiao Z. m6A RNA modification modulates PI3K/Akt/mTOR signal pathway in Gastrointestinal Cancer. Theranostics. 2020 Jul 25;10(21):9528-9543.

7. Xu Wu^#, Jing Shen^#, Zhangang Xiao, Jing Li, Yueshui Zhao, Qijie Zhao, Chi Hin Cho*, Mingxing Li*. An overview of the multifaceted roles of miRNAs in gastric cancer: Spotlight on novel biomarkers and therapeutic targets. Biochemical Pharmacology, 2019(163):425-439. .

8. Wu X#, Hu W#, Lu L#, Zhao Y, Zhou Y, Li X, Li W, Zhang H, Xiao Z, Zhang L, Cho CH, Shen J*, Li MX*. Repurposing Vitamin D for Treatment of Human Malignancies via Targeting Tumor Microenvironment, Acta Pharmaceutica Sinica B. 2019;9(2):203–219.

9. Xu Z, Xia Y, Xiao Z, Jia Y, Zhu Y, Jin Y, Zhao Q, Wan L, Yi T, Yu Y, Zhu Y, Zhang F, Shen J*. Comprehensive profiling of JMJD3 in gastric cancer and its influence on patient survival. Scientific Reports. 2019, 9(1):868.

10. Xu ZY^, Shen J^, Wang MH, Yi T, Yu YY, Zhu YX, Chen B, Chen JP, Li LF, Li MX, Zuo J, Jiang H, Zhou DX, Luan J, Xiao Z. Comprehensive molecular profiling of the B7 family of immune-regulatory ligands in breast cancer. OncoImmunology. Accepted.

11. Shen J, Li ZJ, Li LF, Lu L, Xiao Z, Wu WK, Zhang L, Li MX, Hu W, Chan KM, Cho CH. Vascular-targeted TNFα and IFNγ inhibits orthotopic colorectal tumor growth. J Transl Med. 2016 Jun 24;14(1):187.
    

12. Shen J, Xiao Z, Wu WK, Wang MH, To KF, Chen Y, Yang W, Li SM, Shin VY, Tong JH, Kang W, Zhang L, Li M, Wang L, Lu L, Chan RLY, Wong SH, Yu J, Chan MTV, Chan FKL, Sung JJY, Cheng ASL, Cho CH. (2015). Epigenetic silencing of miR-490-3p reactivates the chromatin remodeler SMARCD1 to promote Helicobacter pylori-induced gastric carcinogenesis. Cancer Res. 15;75(4):754-65.

13. Shen J, Li WX, Xiao ZG, Zhang L, Li MX, Li LF, Hu W, Lu L, Boudreau F, Cho CH. The Co-regulatory Role of 5-Lipoxygenase and Cyclooxygenase-2 in the Carcinogenesis and their Promotion by Cigarette Smoking in Colons. Curr Med Chem. 2016;23(11):1131-8.